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Synthetic cannabinoids have also been employed recreationally simply because they are reasonably priced and are generally not uncovered via the normal cannabis drug assessments.[fifty five] Not like nabilone, the synthetic cannabinoids found being used for leisure use didn't have any documented therapeutic consequences.[38]
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Most artificial cannabinoids are agonists with the cannabinoid receptors. They are already built to be similar to THC,[nine] the normal cannabinoid with the strongest binding affinity into the CB1 receptor, and that is linked to the psychoactive consequences or "high" of marijuana.[ten] These synthetic analogs normally have increased binding affinity and better potency towards the CB1 receptors.
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